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African health sciences · Jun 2008
Anti-seizure activity of the aqueous leaf extract of Solanum nigrum linn (solanaceae) in experimental animals.
- Noel N Wannang, Joseph A Anuka, Helen O Kwanashie, Steven S Gyang, and Asa Auta.
- Dept. of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria. nnwannang1@yahoo.com
- Afr Health Sci. 2008 Jun 1; 8 (2): 747974-9.
BackgroundSolanum nigrum is claimed in traditional medical practice, to be useful in the treatment of epilepsy in some parts of Nigeria.ObjectivesTo study the anti-convulsant property of the aqueous extract of the leaves of S. nigrum in chicks, mice and rats.MethodAqueous extracts were administered intraperitoneally, at a pre-treatment time of 30 minutes, at graded doses and animals were challenged with different types of proconvulsants.ResultsThe aqueous leaf extract produced a significantly (P<0.05) dose dependent protection against electrically-induced seizure in chicks and rats, pentylenetetrazole-induced seizure in mice and rats and picrotoxin-induced seizure in mice and rats. The anti-seizure property of the extract was potentiated by amphetamine.ConclusionThe result obtained in this study suggests that the leaves of this plant may possess anti-convulsant property in chicks, mice and rats.
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