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Mayo Clinic proceedings · Mar 2011
Case ReportsHypertrophic obstructive cardiomyopathy, bleeding history, and acquired von Willebrand syndrome: response to septal myectomy.
- Joseph L Blackshear, Hartzell V Schaff, Steve R Ommen, Dong Chen, and William L Nichols.
- Division of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL 32224, USA. blackshear.joseph@mayo.edu
- Mayo Clin. Proc. 2011 Mar 1; 86 (3): 219224219-24.
AbstractBleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.
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