• Saudi Med J · Oct 2015

    Review

    The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension.

    • Hui-Bo Wang and Jun Yang.
    • Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, Hubei Province, Hubei, China. E-mail. 337380615@qq.com.
    • Saudi Med J. 2015 Oct 1; 36 (10): 115111551151-5.

    AbstractMicro-ribonucleic acids (miRNAs) are small (21-25 nucleotide) single-stranded, evolutionarily conserved non-protein-coding RNAs, which control diverse cellular functions by interacting with the 3' untranslated region of specific target messenger RNAs at the post-transcriptional level. Research shows that an aberrant expression profile of miRNAs has been linked to a series of diseases, including hypertension. In the past few decades, it has been demonstrated that excessive activation of the renin-angiotensin aldosterone system (RAAS) involves in the pathogenesis of hypertension. This article reviews the latest insights in the identification of RAAS-correlative miRNAs and the potential mechanisms for their roles in hypertension.

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