• Maxime D Cuijpers, BaartmansMartin G AMGADepartment of Pediatrics, Maasstad Hospital, Maasstadweg 21, 3079 DZ Rotterdam, the Netherlands., JoostenKoen F MKFMDepartment of Pediatric and Neonatal Intensive Care, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, the Netherlands., Karolijn Dulfer, van ZuijlenPaul P MPPMBurn Center, Red Cross Hospital, Vondellaan 13, 1942 LE Beverwijk, the Netherlands; Plastic, Reconstructive and Hand Surgery, Amsterdam UMC -Location VU University Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Tis, KetJohannes C FJCFMedical Library, VU University, de Boelelaan 1117, 1081 HV Amsterdam, the Netherlands., and Anouk Pijpe.
• Burn Center, Red Cross Hospital, Vondellaan 13, 1942 LE Beverwijk, the Netherlands; Plastic, Reconstructive and Hand Surgery, Amsterdam UMC -Location VU University Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Tissue Function and Regeneration, Amsterdam Movement Sciences, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Association of Dutch Burn Centers, Zeestraat 27-29, 1941 AJ Beverwijk, the Netherlands. Electronic address: mcuijpers@rkz.nl.
• Burns. 2024 Aug 1; 50 (6): 143714551437-1455.

ObjectiveTo evaluate the efficacy of therapeutic interventions on pediatric burn patients' height, weight, body composition, and muscle strength.MethodsA systematic literature search was conducted in PubMed, Embase, and Web of Science up to March 2021. Eligible interventional studies reported metrics on the height, weight, body composition, or muscle strength of pediatric burn patients in a peer-reviewed journal. Meta-analyses were performed if ≥ 2 trials of clinical homogeneity reported on an outcome measure at the same time point post-burn.ResultsTwenty-six interventional studies were identified, including twenty-two randomised controlled trials and four non-randomised trials. Most studies were conducted by a single institution. On average, the burn covered 45.3% ( ± 9.9) of the total body surface area. Three categories of interventions could be distinguished: rehabilitative exercise programs, pharmacologic agents, and nutrition support.ConclusionsEach of the interventions had a positive effect on height, weight, body composition, or muscle strength. The decision to initiate an intervention should be made on a case-by-case basis following careful consideration of the benefits and risks. In future research, it is important to evaluate the heterogeneity of intervention effects and whether participation in an intervention allowed pediatric burn patients to reach the physical and functional status of healthy peers.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

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