• Ross I Donaldson, Jonathan K Armstrong, Oliver J Buchanan, Todd L Graham, John S Cambridge, Nely N Cristerna, Diane Goldenberg, Captain David A Tanen, Timothy C Fisher, Juliana Tolles, Christopher J Burns, and James D Ross.
• Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA; Department of Emergency Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Emergency Medicine, Harbor-UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA; Department of Epidemiology, UCLA - Fielding School of Public Health, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA. Electronic address: rdonaldson@criticalinnovations.com.
• Burns. 2024 Aug 1; 50 (6): 157815851578-1585.

BackgroundThis study compared a novel topical hydrogel burn dressing (CI-PRJ012) to standard of care (silver sulfadiazine) and to untreated control in a swine thermal burn model, to assess for wound healing properties both in the presence and absence of concomitant bacterial inoculation.MethodsEight equal burn wounds were created on six Yorkshire swine. Half the wounds were randomized to post-burn bacterial inoculation. Wounds were subsequently randomized to three treatments groups: no intervention, CI-PRJ012, or silver sulfadiazine cream. At study end, a blinded pathologist evaluated wounds for necrosis and bacterial colonization.ResultsWhen comparing CI-PRJ012 and silver sulfadiazine cream to no treatment, both agents significantly reduced the amount of necrosis and bacteria at 7 days after wound creation (p < 0.01, independently for both). Further, CI-PRJ012 was found to be significantly better than silver sulfadiazine (p < 0.02) in reducing bacterial colonization. For wound necrosis, no significant difference was found between silver sulfadiazine cream and CI-PRJ012 (p = 0.33).ConclusionsCI-PRJ012 decreases necrosis and bacterial colonization compared to no treatment in a swine model. CI-PRJ012 appeared to perform comparably to silver sulfadiazine. CI-PRJ012, which is easily removed with the application of room-temperature water, may provide clinical advantages over silver sulfadiazine.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

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