• Hongwei Fang, Qianhao Hou, Wei Zhang, Zehua Su, Jinyuan Zhang, Jingze Li, Jiaqi Lin, Zetian Wang, Xiuqin Yu, Yu Yang, Qing Wang, Xin Li, Yuling Li, Lungui Hu, Shun Li, Xiangrui Wang, and Lijun Liao.
• Department of Pain Management, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Pain Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
• J Pain. 2024 Sep 1; 25 (9): 104535104535.

AbstractFibromyalgia (FM) is a complex and poorly understood disorder characterized by chronic and widespread musculoskeletal pain, of which the etiology remains unknown. Now, the disorder of the gut microbiome is considered as one of the main causes of FM. This study aimed to investigate the potential benefits of fecal microbiota transplantation (FMT) in patients with FM. A total of 45 patients completed this open-label, randomized, nonplacebo-controlled clinical study. The numerical rating scale scores in the FMT group were slightly lower than the control group at 1 month (P > .05), and they decreased significantly at 2, 3, 6, and 12 months after treatment (P < .001). Besides, compared with the control group, the Widespread Pain Index, Symptom Severity, Hospital Anxiety and Depression Scale, and Pittsburgh Sleep Quality Index scores were significantly lower in the FMT group at different time points (P < .001). After 6 months of treatment, there was a significant increase in serotonin (5-hydroxytryptamine) and gamma-aminobutyric acid levels (P < .001), while glutamate levels significantly decreased in the FMT group (P < .001). The total effective rate was higher in the FMT group (90.9%) compared to the control group (56.5%) after 6 months of treatment (P < .05). FMT can effectively improve the clinical symptoms of FM. With the close relations between the changes in neurotransmitters and FM, certain neurotransmitters may serve as a diagnostic marker or potential target for FM patients. PERSPECTIVE: FMT is a novel therapy that aims to restore the gut microbial balance and modulate the gut-brain axis. It is valuable to further explore the therapeutic effect of FMT on FM. Furthermore, certain neurotransmitters may become a diagnostic marker or a new therapeutic target for FM patients.Copyright © 2024. Published by Elsevier Inc.

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