• Dilek Dilli, Izzet Göker Küçük, and Yildiz Dallar.
• Department of Paediatrics, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey. dilekdilli2@yahoo.com
• J. Pediatr. 2009 Mar 1;154(3):385-90.

ObjectiveTo investigate interventions that affect pain reduction during vaccination in infants and children attending a well-child unit.Study DesignA consecutive sample of 243 children between age 0 and 48 months receiving their routine vaccinations was randomly assigned to 1 of the study groups. A total of 158 infants under age 6 months were randomly assigned to breast-feeding or no breast-feeding during immunization, and 85 children age 6 to 48 months were randomly assigned to receive 12% sucrose solution, lidocaine-prilocaine cream, or no intervention. All children were evaluated for crying time and pain score by a pediatrician using the Neonatal Infant Pain Scale (NIPS) for those under age 12 months and the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) for those over age 12 months.ResultsBreast-feeding in infants under age 6 months and use of sucrose or lidocaine-prilocaine in children age 6 to 48 months significantly reduced crying time and pain scores compared with controls. No difference in outcome was seen between the sucrose and lidocaine-prilocaine treatment groups.ConclusionsHere we expand on previous findings by demonstrating that breast-feeding may have an analgesic effect up to age 6 months and that in older children, both sucrose and lidocaine-prilocaine reduce vaccination pain.

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