• World Neurosurg · Jul 2024

    Review

    The potential of liquorpheresis to treat leptomeningeal disease.

    • Victor M Lu, Ashish H Shah, and Manuel Menéndez González.
    • Department of Neurological Surgery, University of Miami, Miami, Florida, USA. Electronic address: victor.lu@jhsmiami.org.
    • World Neurosurg. 2024 Jul 1; 187: 939893-98.

    AbstractLeptomeningeal disease (LMD) is a devastating sequela of many cancers, with an extremely poor prognosis. Barriers to improving outcomes are related to the inability of many traditional therapies to effectively reach the cerebrospinal fluid (CSF) space within the central nervous system. Liquorpheresis is an emerging treatment modality specific to CSF diseases, the primary mechanism of action of which is direct targeted filtration of CSF content by neurosurgical access. In this review, we highlight the principles of liquorpheresis and detail how LMD can be amenable to this treatment. Further, we summarize the current in vitro and in vivo evidence supporting liquorpheresis as a feasible method to treat LMD and other central nervous system diseases as well as describe its conceivable limitations.Copyright © 2024 Elsevier Inc. All rights reserved.

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