• African health sciences · Jun 2013

    Case Reports Historical Article

    Nodding syndrome: origins and natural history of a longstanding epileptic disorder in sub-Saharan Africa.

    • P S Spencer, V S Palmer, and L Jilek-Aall.
    • Department of Neurology, School of Medicine; Senior Scientist, Center for Research on Occupational and Environmental Toxicology, and Director, Global Health Center, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, L356, Portland, Oregon 97239, USA.
    • Afr Health Sci. 2013 Jun 1; 13 (2): 176182176-82.

    BackgroundRepetitive involuntary head nodding was first reported in the 1960s in the Wapogoro tribe of Tanzania.ObjectivesWe describe the natural history of head nodding in the Wapogoro tribe, with special reference to the earliest reported dates of onset.MethodsWe analyzed clinical data from 150 historical patients seen between 1960 and 1971.ResultsHead nodding with or without grand mal convulsions was present in 33/150 (∼20%) cases, was mostly familial and equally distributed by gender. Age at onset of head nodding ranged from 2-22 years (mean: ∼10 years) in the period 1934-1962. Head nodding preceded onset of grand mal convulsions by up to 12 months, and motor and psychomotor deficits indicative of brain damage developed with time. Fourteen of the 33 cases died at 13-39 years of age (mean: ∼20 years) while nineteen aged 16-28 years (mean: ∼16 years) were still alive.ConclusionHistorical accounts of head nodding (amesinzia kichwa, Swahili) among the Wapogoro tribe fit the August 2012 World Health Organization (WHO) case definition of probable Nodding Syndrome. Reported to have existed in this population for at least 80 years, Nodding Syndrome is a progressive seizure disorder that leads to generalized convulsions (kifafa), brain damage and death.

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