• Arch Med Sci · Jan 2024

    Telomeres and telomerase in endometrial cancer and hyperplasia.

    • Anna Pańczyszyn, Ewa Boniewska-Bernacka, Karolina Włodarczyk, Iwona Wertel, and Anna Goc.
    • Institute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Opole, Poland.
    • Arch Med Sci. 2024 Jan 1; 20 (2): 682685682-685.

    IntroductionThe study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.MethodsTotal RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.ResultsThe control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.ConclusionsTelomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.Copyright: © 2024 Termedia & Banach.

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