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Mayo Clinic proceedings · Jul 2024
ReviewOxalate Metabolism: From Kidney Stones to Cardiovascular Disease.
- Gerlineke Hawkins-van der Cingel, Stephen B Walsh, Kai-Uwe Eckardt, and Felix Knauf.
- Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany; UCL Department of Renal Medicine, University College London, London, United Kingdom. Electronic address: gerlineke.hawkins.van-der-cingel@charite.de.
- Mayo Clin. Proc. 2024 Jul 1; 99 (7): 114911611149-1161.
AbstractOxalate kidney stones are common and exert a huge burden of morbidity worldwide. However, circulating or excreted concentrations of oxalate are rarely measured. We argue that oxalate and its metabolism are important above and beyond kidney stone formation. There is emerging evidence that increased concentrations of oxalate could be a driver of chronic kidney disease progression. Furthermore, oxalate has been implicated in cardiovascular disease. Thus, the reduction of elevated plasma oxalate concentrations may represent a novel cardioprotective and nephroprotective strategy.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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