• Mayo Clinic proceedings · Jun 2024

    Review

    Rise to the Challenge: Master the Management of Clostridioides difficile Infection.

    • Elida Voth and Sahil Khanna.
    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
    • Mayo Clin. Proc. 2024 Jun 1; 99 (6): 971979971-979.

    AbstractClostridioides difficile infection (CDI) is a significant public health challenge in the developed world. Although previously CDI was primarily a health care-acquired infection, there are now rising numbers of community-acquired cases in patients without traditional risk factors, such as antibiotic exposure. The landscape for the treatment of CDI has changed significantly during the past decade, including newer diagnostic tests, novel antibiotic regimens, and strategies for microbiome restoration in the form of traditional fecal microbiota transplant and approved live biotherapeutics in an effort to address the underlying pathophysiologic process of gut microbial dysbiosis. We present a concise review for clinicians on the diagnosis and management of both primary and recurrent CDI.Copyright © 2024 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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