• Neuroscience · Jul 2024

    Review

    Advances in circular RNA in the pathogenesis of epilepsy.

    • Qin Wang, Baijun Qin, Haichun Yu, Yueqiang Hu, Han Yu, Jie Zhong, Jinwen Liu, Chunyuan Yao, Jiawei Zeng, Jingjing Fan, and Limei Diao.
    • Graduate School of First Clinical Medicine College, Guangxi University of Chinese Medicine, 13 Wuhe Avenue, Qingxiu District, Nanning, Guangxi 530001, China; Department of Neurology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, 89-9 Dongge Road, Qingxiu District, Nanning, Guangxi 530023, China.
    • Neuroscience. 2024 Jul 23; 551: 246253246-253.

    AbstractRecent studies evidenced the involvement of circular RNA (circRNA) in neuroinflammation, apoptosis, and synaptic remodeling suggesting an important role for circRNA in the occurrence and development of epilepsy. This review provides an overview of circRNAs considered to be playing regulatory roles in the process of epilepsy and to be involved in multiple biological epilepsy-related processes, such as hippocampal sclerosis, inflammatory response, cell apoptosis, synaptic remodeling, and cell proliferation and differentiation. This review covers the current research status of differential expression of circRNA-mediated seizures, m6A methylation, demethylation-mediated seizures in post transcriptional circRNA modification, as well as the mechanisms of m5C- and m7G-modified circRNA. In summary, this article reviews the research progress on the relationship between circRNA in non-coding RNA and epilepsy.Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved.

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