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- Ülkü Türk Börü, Arda Duman, Cem Bölük, Sanem Coşkun Duman, and Mustafa Taşdemir.
- Department of Neurology, Dr. Lütfi Kırdar Kartal Training and Research Hospital Department of Neurology, Maltepe State Hospital Department of Public Health, Bezmialem University, Istanbul, Turkey.
- Medicine (Baltimore). 2017 Sep 1; 96 (39): e8133e8133.
BackgroundBotulinum toxin type-A (BTX-A) has been successfully utilized to treat trigeminal neuralgia. In this study, through the use of a new technique, the efficacy of the injection of BTX-A to the maxillary and mandibular nerves was evaluated.MethodsA total of 27 patients were injected with 100 Units of BTX-A to the maxillary and mandibular nerves. Visual analogue scale score and pain frequency were assessed before treatment and at the first week, second month, and sixth month after treatment. Patients with ≥50% reduction in mean pain score at the second and sixth month were defined as responders.ResultsA total of 27 patients were included in the study. BTX-A significantly reduced pain intensity and pain attack frequency at the first week, second month, and sixth month after treatment. At the second month, 74.1% of patients, at the sixth month, 88.9% of patients responded to treatment. Forty-four percent of patients did not experience any pain at the sixth month. The mean recurrence period was 87.7 ± 20.4. BTX-A was well tolerated and showed few treatment-related adverse events.ConclusionInjection to the maxillary and mandibular roots seems to be a highly effective method. In the event of recurrence, after each injection, the pain severity and attack frequency decreased.
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