• Respiratory care · Sep 2024

    A Summed Score From Cardiopulmonary Exercise Test Parameters Predicts 1-Year Mortality in Newly Diagnosed Interstitial Lung Disease.

    • Yuan-Yang Cheng, Yu-Chun Lee, Yu-Wan Liao, Ming-Cheng Liu, Yu-Cheng Wu, Chiann-Yi Hsu, Yi-Hsuan Yu, and Pin-Kuei Fu.
    • Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung 40705, Taiwan; and Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40200, Taiwan.
    • Respir Care. 2024 Sep 26; 69 (10): 130513131305-1313.

    BackgroundCardiopulmonary exercise testing (CPET) is a unique diagnostic tool that assesses the functional capacity of the heart, lungs, and peripheral oxidative system in an integrated manner. However, the clinical utility of CPET for evaluating interstitial lung disease (ILD) remains uncertain. The objective of this study was to determine the predictive value of CPET for mortality in subjects with ILD.MethodsWe prospectively enrolled subjects with ILD who underwent CPET at a tertiary medical center in Taiwan and followed up their survival status for 12 months. Mortality prediction was based on comparing CPET parameters between subjects who survived and those who died. We further analyzed CPET parameters that showed significant differences using receiver operating characteristic curves to identify their optimal cutoff values.ResultsA total of 106 newly diagnosed subjects with ILD underwent CPET, and the 1-y mortality rate was 7.5%. Six CPET variables were found to be significant predictors of mortality: peak oxygen consumption, oxygen pulse, end-tidal partial pressure of carbon dioxide, heart rate recovery 1 min after CPET, minute ventilation to carbon dioxide output slope, and functional aerobic impairment. We calculated a summed score by adding the number of CPET variables that exceeded their cutoff values. Subjects with a summed score of 6 had a 1-y survival rate of only 25%, whereas subjects with scores of 0-5 had a survival rate of 98%.ConclusionsIn conclusion, the summed score represents a useful tool for screening patients with ILD who can undergo a CPET to determine their prognosis.Copyright © 2024 by Daedalus Enterprises.

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