• Chunsheng Huang, Jun Qiu, and XiangMing Fang.
• Department of Anesthesiology and Intensive Care, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China; Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
• J. Cardiothorac. Vasc. Anesth. 2024 Oct 1; 38 (10): 224722532247-2253.

ObjectiveTo examine the association of an elevated level of uric acid (UA) in the bloodstream with an increased likelihood of acute kidney injury (AKI) following coronary artery bypass grafting (CABG) surgery.DesignRetrospective cohort study using a multivariate logistic regression model.SettingSingle institution.ParticipantsRecipients of CABG surgery.InterventionNone.Measurements And Main ResultsA total of 761 individuals who underwent CABG were included in the study. The participants were categorized into 4 groups based on their UA level: Q1 group (UA <292.5 μmol/L), Q2 group (292.5 ≤ UA <353 μmol/L), Q3 group (353 ≤ UA < 423 μmol/L), and Q4 group (UA ≥423 μmol/L). A total of 167 patients, accounting for 21.9% of the sample, experienced postoperative AKI. The study found a significantly higher risk of AKI in the Q4 group compared to the Q1 group (40.4% v 8.9%; p < 0.001). After adjustment for confounding variables, an independent association between serum UA concentration and an elevated risk of AKI post-CABG was identified (odds ratio, 6.41; 95% confidence interval, 3.49-12.32; p < 0.001; p for trend < 0.001).ConclusionsThere is a relationship between preoperative blood UA level and the occurrence of AKI following CABG surgery.Copyright © 2024 Elsevier Inc. All rights reserved.

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