• Yize Li, Luyao Zhang, Guona Zheng, Jing Li, Zhourun Ma, Xiuchuan Jia, and Yingmin Chen.
• Department of Radiology, Hebei General Hospital, Shijiazhuang, Hebei, China.
• Medicine (Baltimore). 2024 Jul 5; 103 (27): e38796e38796.

RationaleMyxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade malignant soft tissue sarcoma that primarily affects the distal extremities in adults, with the highest incidence in patients in their 40s and 50s. It has a high local recurrence rate and a low metastasis rate. Although MIFSs have been documented in other sites, an MIFS in the liver is highly unusual. Herein, we present a case of a patient with hepatic MIFS.Patient ConcernsThe patient was a 58-year-old Chinese man with abdominal pain as the primary symptom. Abdominal computed tomography and magnetic resonance imaging revealed a mass in the right posterior lobe of the liver. The patient underwent surgical excision, and the excised specimen was identified as MIFS. Three years later, the patient returned to our hospital for abdominal pain. Computed tomography and magnetic resonance imaging revealed a mass in liver segments 2/3/4.DiagnosisPostoperative pathological examination of the tumor revealed the recurrence of MIFS.InterventionsThe patient underwent surgical resection of the MIFS.OutcomesThe patient received multiple pirarubicin-based chemotherapy treatments and an ALK inhibitor (anlotinib) within 6 months after surgery, but the tumor recurred.LessonsMIFS can not only occur in the proximal limbs, trunk, head, and neck but can also affect the abdominal organs. Surgical resection remains the primary treatment option for MIFS in the absence of any contraindications. Because the recurrence rate of MIFS is high, meticulous long-term monitoring is required.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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