• Belgin Devranoğlu, Müşerref Banu Yilmaz, Gamze Peker, Özlen Emekçi Özay, Ali Cenk Özay, and Ali İrfan Güzel.
• Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Health Sciences University, İstanbul, Turkey.
• Medicine (Baltimore). 2024 Jul 12; 103 (28): e38902e38902.

AbstractThe aim of this study is to evaluate the risk factors for empty follicle syndrome (EFS) in patients with diminished ovarian reserve (DOR) undergoing an intracytoplasmic sperm injection cycle. In this retrospective study, patients with DOR were divided into 2 groups according to the presence of empty follicles on the day of oocyte retrieval. Patient age, body mass index (BMI), anti-Müllerian hormone (AMH), baseline follicle stimulating hormone (FSH) and estradiol (E2) levels, basal antral follicle count (AFC), total gonadotropin dose, and day of stimulation were recorded as risk factors. The association between EFS and these variables was assessed using the logistic regression method and ROC curve analysis. Increased BMI, low AMH, higher baseline FSH, low baseline AFC, higher gonadotropin dose, and longer day of ovulation induction were independent risk factors for EFS in patients with DOR. ROC curve analysis showed that BMI, AMH, baseline FSH, baseline AFC, higher gonadotropin dose, and longer ovulation induction days were predictive parameters in this group. According to the current study, higher BMI, lower AMH, higher baseline FSH, lower baseline AFC, higher gonadotropin dose and longer ovulation induction days were independent risk factors for EFS in patients with reduced ovarian reserve.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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