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Observational Study
Significance of family history of cholelithiasis in a Pakistani population: A single center, descriptive cross-sectional study.
- Mansab Ali, Amir Usman, Javeria Usman, Muhammad Abid, Wafa Najeeb, Muhammad Imran, and Nour Fakih.
- Department of General Surgery, The University of Lahore Teaching Hospital, Lahore, Pakistan.
- Medicine (Baltimore). 2024 Jul 12; 103 (28): e38925e38925.
AbstractLinkage studies have indicated a potential genetic predisposition to cholelithiasis. This study aims to determine the frequency of positive family history of gallstone disease in patients presenting with gallstones in a Pakistani population. A descriptive, cross-sectional study was conducted at the surgical department of the University of Lahore Teaching Hospital from June 30, 2023 to August 30, 2023. A total of 102 radiologically confirmed cholelithiasis patients were enrolled. Out of 102 participants, 75.5% (n = 77) were females, with a mean age at presentation of 42.1 ± 12.1 years. The study found that 32.4% (n = 33) of participants had a single family member with gallstones, 3.9% (n = 4) had 2 family members affected, and 1% (n = 1) had 3 family members affected. The attributable risk of genetics from our study was 37.2%. Additionally, there was no significant association between positive family history and earlier onset of disease. A significant percentage of Pakistani population may have gallstone disease due to genetic factors.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
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