• Medicine · Jul 2024

    Review

    Involvement of serotonergic receptors in depressive processes and their modulation by β-arrestins: A review.

    • Aldo R Tejeda-Martínez, Ana R Ramos-Molina, Patricia A Brand-Rubalcava, and Mario E Flores-Soto.
    • Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara, México.
    • Medicine (Baltimore). 2024 Jul 12; 103 (28): e38943e38943.

    AbstractOver time, several studies have been conducted to demonstrate the functions of the neurotransmitter 5-hydroxytryptamine (5-HT), better known as serotonin. This neurotransmitter is associated with the modulation of various social and physiological behaviors, and its dysregulation has consequences at the behavioral level, leading to various neurophysiological disorders. Disorders such as anxiety, depression, schizophrenia, epilepsy, sexual disorders, and eating disorders, have been closely linked to variations in 5-HT concentrations and modifications in brain structures, including the raphe nuclei (RN), prefrontal cortex, basal ganglia, hippocampus, and hypothalamus, among others. The involvement of β-arrestin proteins has been implicated in the modulation of the serotonergic receptor response, as well as the activation of different signaling pathways related to the serotonergic system, this is particularly relevant in depressive disorders. This review will cover the implications of alterations in 5-HT receptor expression in depressive disorders in one hand and how β-arrestin proteins modulate the response mediated by these receptors in the other hand.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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