• Yuanting Su and Wei Cui.
• Department of Dermatology, The Second People's Hospital of Hefei, Hefei, Anhui, China.
• Medicine (Baltimore). 2024 Jul 19; 103 (29): e39071e39071.

IntroductionAcquired reactive perforating collagenosis (ARPC) is a rare perforating skin disease with unclear pathogenesis, often leading to misdiagnosis. Utilizing noninvasive skin microscopy improves diagnostic accuracy while reducing misdiagnosis rates.Patient ConcernsGiven its association with systemic diseases, comprehensive examinations are crucial for early detection of related diseases such as tumors. Clinically, it still lacks standardized guidelines for the treatment. Clinical treatment is mostly based on symptomatic treatment. Oral administration of pregabalin capsules can significantly relieve itching symptoms, and narrow-wave ultraviolet irradiation can accelerate the recovery of skin lesions.DiagnosisDermoscopy and skin biopsy was used to confirm this case was ARPC.InterventionsTreatment was based on oral administration of 20 mg prednisone, 1 tablet of loratadine, 1 tablet of pregabalin in the morning and evening, and external application of halomethasone ointment.OutcomesItching symptoms were significantly relieved.ConclusionThis case report demonstrates that clinical dermoscopy can improve the diagnosis rate of ARPC, and pregabalin capsules can significantly relieve itching symptoms.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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