• Ziyi Zhao, Chunhua Pan, Junting Chen, Rui Wu, Zucai Xu, and Hao Huang.
• Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
• Medicine (Baltimore). 2024 Jul 19; 103 (29): e38966e38966.

RationaleNeuromyelitis optica spectrum disorder (NMOSD) involves autoimmune and inflammatory responses in the central nervous system, primarily affecting the optic nerves and spinal cord. Atypical presentations such as ataxia and syncope complicate the diagnosis, and lesions in the medulla are easily mistaken for cerebral infarction. This case report emphasizes the need to recognize such manifestations to avoid misdiagnosis and ensure timely treatment.Patient ConcernsThis case report presents an NMOSD female patient who experienced ataxia, syncope, and neuropathic pain during her illness.DiagnosisNMOSD.InterventionsThe patient managed her blood sugar with insulin, controlled neuropathic pain with pregabalin, and underwent 5 plasma exchanges.OutcomesSignificant improvement was noted 1 week post-plasma exchange, with complete resolution of neuropathic pain and no symptom recurrence reported at 6-month follow-up.LessonsAtypical manifestations of NMOSD, such as ataxia, syncope, and trigeminal neuralgia, increase diagnostic difficulty. Recognizing these symptoms is crucial to avoid misdiagnosis and ensure timely and appropriate treatment for patients.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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