• Medicine · Feb 2019

    Case Reports

    A rare primary Candida parapsilosis infection of the knee joint in a patient without predisposing factors: A case report.

    • Jun Wang, Zhen Zhang, Miao Zhang, Bo Yang, Tengyun Wang, Xuedong Sun, Xiuli Chen, Min Yi Zhang, Zhi Yong Guo, and Xin Jiang.
    • Department of Joint Surgery, Weifang People's Hospital, Shandong, China.
    • Medicine (Baltimore). 2019 Feb 1; 98 (6): e14327e14327.

    RationalKnee joint infection caused by isolated primary Candida is extremely rare, with only a few cases reported. It occurs most often in patients with predisposing factors (e.g., immunosuppression, malignancy, drug abuse) or fungal invasion during traumatic procedures, including surgery. We report an unusual case of Candida parapsilosis infection in the knee joint with no predisposing factors.Patient ConcernsA 65-year-old man entered our hospital complaining of persistent pain and mild swelling of the right knee that seriously affected normal walking. There was no obvious cause for his distress.DiagnosisThe case was eventually diagnosed as a primary Candida parapsilosis infection which had many diagnostic particularities and difficulties.InterventionsTotal knee arthroplasty (TKA) was ultimately performed followed by fluconazole coverage.OutcomesThe patient showed good clinical performance at the 3- and 6-month follow-up visits and was very satisfied with the therapeutic effect.LessonsIf there were suspected symptoms of primary Candida infection cases, imaging and microscopic examinations, tissue cultures, and pathological examination of the puncture knee joint fluid were required.

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