• Saranya Lertkovit, Kamheang Vacharaksa, Chaowanan Khamtuikrua, Teerapong Tocharoenchok, Angsu Chartrungsan, Nipaporn Sangarunakul, and Aphichat Suphathamwit.
• Division of Cardiothoracic Anesthesia, Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
• J. Cardiothorac. Vasc. Anesth. 2024 Oct 1; 38 (10): 232423332324-2333.

ObjectiveTo compare the analgesic and sleep quality effects of dexmedetomidine infusion versus placebo in patients undergoing cardiac surgery with ultra-fast track extubation.DesignThe randomized, double-blind clinical trial study.SettingAt a single academic center hospital.ParticipantsWe included patients aged 25 to 65 scheduled for elective cardiac surgery under general anesthesia with cardiopulmonary bypass from October 2021 to December 2022.InterventionAfter immediate extubation in the operating room, the patients who were allocated at first after providing their consent to either the dexmedetomidine group (Dex) or the placebo group (Placebo) received continuous infusion of dexmedetomidine (0.2 μg/kg/h) or saline for 12 hours postoperatively.Measurements And Main ResultsThe groups' demographic and perioperative variables were not statistically significant. Total morphine consumption in milligrams at 12 and 24 hours after administered study drug, total sleep time in hours by BIS value ≤85, and sleep quality with the Richard-Campbell Sleep Questionnaire were compared. The analysis included 22 Dex and 23 Placebo patients. The consumption of morphine was not statistically different between the Dex and Placebo groups at 12 and 24 hours (p = 0.707 and p = 0.502, respectively). The Dex group had significantly longer sleep time (8.7 h [7.8, 9.5]) than the Placebo group (5.8 h [2.9, 8.5]; p = 0.007). The Dex group also exhibited better sleep quality (7.9 [6.7, 8.7] vs 6.6 [5.2, 8.0]; p = 0.038).ConclusionsSedation with low-dose dexmedetomidine infusion for ultra-fast track extubation following cardiac surgery enhances sleep duration and quality.Copyright © 2024 Elsevier Inc. All rights reserved.

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