• Neuroscience · Aug 2024

    Randomized Controlled Trial

    Alcohol drinking modified the effect of plasma YKL-40 levels on stroke-specific mortality of acute ischemic stroke.

    • Ziyi Wang, Kaixin Zhang, Chongke Zhong, Zhengbao Zhu, Xiaowei Zheng, Pinni Yang, Bizhong Che, Yaling Lu, Yonghong Zhang, and Tian Xu.
    • Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China.
    • Neuroscience. 2024 Aug 6; 552: 152158152-158.

    ObjectivesOur study aimed to evaluate the association between plasma human cartilage glycoprotein-39 (YKL-40) and stroke-specific mortality at two years in acute ischemic stroke patients according to the drinking status and amount of alcohol consumption. We further investigated the effect of the interaction between these conditions and YKL-40 levels on the outcome.MethodsWe measured plasma YKL-40 levels in 3267 participants from the China Antihypertensive Trial in Acute Ischemic Stroke. Outcome data on stroke-specific mortality were collected at two years after stroke onset.ResultsDuring the two years of follow-up, 208 (6.4 %) patients, including 44 drinkers and 164 nondrinkers, died of stroke-specific causes. The patients in the highest quartile of YKL-40 had a 3.52-fold (95 % CI: 1.15-10.76, P for trend = 0.006) risk of stroke-specific mortality compared with those in the lowest quartile among drinkers. However, no significant association between YKL-40 and the outcome was observed among nondrinkers (HR: 1.18, 95 % CI: 0.75-1.86, P for trend = 0.08). Alcohol drinking modified the effect of YKL-40 on the outcome (P for interaction = 0.04). Subgroup analyses revealed that each 1-unit increase in log-transformed YKL-40 was associated with a 72 % greater risk of stroke-specific mortality for light drinkers. This association was amplified with a 226 % increased risk of the outcome among heavy drinkers.ConclusionsElevated YKL-40 levels were associated with an increased risk of stroke-specific mortality at two years among drinkers with ischemic stroke. Drinking status substantially modified the effect of plasma YKL-40 levels on the outcome. This effect was amplified with the increased amount of alcohol consumption.RegistrationURL: https://www.Clinicaltrialsgov; Unique identifier: NCT01840072.Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved.

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