• Hossam Tharwat Ali, Ziad Ashraf Soliman, Firas Aborigiba, Ana Leticia Fornari Caprara, and Jamir Pitton Rissardo.
• Qena Faculty of Medicine, South Valley University, Egypt.
• Afr Health Sci. 2024 Mar 1; 24 (1): 206212206-212.

IntroductionTrazodone is an antidepressant agent approved for treating major depressive disorders and is also prescribed for insomnia due to its sedative effect. In a few cases, trazodone was associated with parkinsonism. Herein, we describe a case of parkinsonism after a brief exposure to a moderate dose of trazodone.ObjectiveTo describe a case of a patient with trazodone-induced parkinsonism in which the diagnosis was suspected after the exclusion of other common and serious causes.MethodsA case report of trazodone-induced parkinsonism.Clinical CaseA 58-year-old male with sleeping problems was prescribed trazodone 50 mg daily at bedtime. The subject doubled the dosage without medical advice a week later. After 14 days of trazodone treatment, he started to experience difficulty in moving his upper limbs and recurrent falling. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable. Trazodone was discontinued, and the patient fully recovered. Noteworthy, the patient developed a recurrence of the motor symptoms with trazodone-rechallenge.ConclusionOur case showed reversibly induced parkinsonism after a short intake of a moderate dose of trazodone which was prescribed for insomnia. The patient had a complete recovery after trazodone withdrawal. Noteworthy, the symptoms recurred upon trazodone-rechallenge.© 2024 Ali HT et al.

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