• Moueden Amine, Messaoudi Reda, and Derouiche Mokhtar.
• Université d'Oran 1 Ahmed Ben Bella Faculté de Médecine, Pharmacie.
• Afr Health Sci. 2023 Dec 1; 23 (4): 102107102-107.

IntroductionThe causative agent of COVID-19 (Coronavirus Disease 2019) is an enveloped RNA (ribonucleic acid) virus of the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) family. The effects of SARS-CoV-2 on the differentiation and maturation of blood cells have been the subject of several studies, we report our experience of an investigation of the morphologic abnormalities of leukocytes observed during COVID-19.Patients And MethodsThis is a prospective study of 5 months, from February 2021 to June 2021. Forty COVID-19 patients and 20 healthy controls were included in this study. We performed complete blood count and peripheral blood smear of all patients and control samples. Leukocytes abnormalities were quantified as a percentage of 100 leukocytes of the same lineage.ResultsThe morphological abnormalities of the leukocytes found in percentage of patients have been mainly neutrophils bilobed 72,5%, hypogranulation 45%, acquired pseudo Pelger-Huet 35%, vacuolated neutrophils 42,5%, Apoptotic neutrophils 35,5 %, neutrophils with toxic granulations 30%, myelemia 45%, atypical lymphocytes 52,5%, lymphoplasmocytes 60% and vacuolated monocytes 27, 5%.ConclusionOur study revealed several morphological abnormalities of the different cells of the leukocyte lineage. The presence of toxic granulations in the cytoplasm of the myelocytes was specific to this study.© 2023 Amine M et al.

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