• Ahmad A Alshehri, Adebayo IrekeolaAhmadAFrom the Department of Clinical Laboratory Sciences (Alshehri, Alshahrani MM, Asiri, Al Awad, Alhasaniah, Almazni, Alshamrani, Elnoubi), College of Applied Medical Sciences, Najran University; from the Health Research Center (Alshehr, Mohammed Merae Alshahrani, Khaja Shameem Mohammed Abdul, Saeed Ahmed Asiri, Banan F Aboluluy, Ahmed Abdullah Al Awadh, Abdulaziz Hassan Alhasaniah, Ibrahim Abdullah Almazni, Saleh A Alshamrani, Abdullah J Alshahrani, Ahmad M Saif, Osman Ae Elnoubi, Abdulrahim R Hakami, Abdulrazzag Abdulaziz Othman, and Mansor H Almohi.
• From the Department of Clinical Laboratory Sciences (Alshehri, Alshahrani MM, Asiri, Al Awad, Alhasaniah, Almazni, Alshamrani, Elnoubi), College of Applied Medical Sciences, Najran University; from the Health Research Center (Alshehri), Najran University; from the Department of Clinical Laboratory Sciences (Aboluluy), Najran University Hospital, Najran University, Najran; from the Department of Public Health (Alshahrani AJ), General Directorate of Health Affairs in Asir Region, Asir; from the Department of Clinical Laboratory Sciences (Saif, Hakami), College of Applied Medical Sciences, King Khalid University, Abha; from the Department of Pathology and Medical Laboratory - Molecular Genetics (Almohi), University Hospital, King Khalid University, Abha; from the Department of Clinical Laboratory Sciences (Othman), College of Applied Medical Sciences, Shaqra University, Shaqra, Kingdom of Saudi Arabia; from the Department of Medical Microbiology & Parasitology (Irekeola), School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; from the Microbiology Unit, Department of Biological Sciences (Irekeola), College of Natural and Applied Sciences, Summit University Offa, Kwara, Nigeria; and from the Cardiovascular Signaling Division (Mohammed Abdul), Huntington Medical Research Institutes, California, United States of America.
• Saudi Med J. 2024 Jul 1; 45 (7): 667674667-674.

ObjectivesTo ascertain the prevalence of transfusion transmissible infections (TTIs) across diverse donor groups in the Najran province. Additionally, to establish a potential association between the development of TTI and the donors' blood group, as determined by the ABO/Rh blood grouping system.MethodsBlood donation data of 4120 donors, spanning from January to December 2020, were retrospectively reviewed. The blood were screened for TTI markers, including hepatitis B surface antigen (HBsAg), anti-hepatitis B core (anti-HBc), anti-hepatitis C virus (anti-HCV), anti-human immunodeficiency viruses 1 and 2 (anti-HIV1&2), anti-human T-lymphotropic virus types 1 and 2 (anti-HTLV-1&2), and syphilis antigen.ResultsPositive TTI markers were detected in 10.9% of the donors. The most detected TTI marker was anti-HBc (8.9%), followed by HBsAg (0.7%). Other markers were individually detected in <1% of the donors. Anti-HBc-positive was significantly elevated among non-Saudi blood donors. There was an association between age groups and anti-HCV (p=0.002), anti-HTLV (p=0.004) and syphilis antigen (p=0.02) markers positivity. The AB positive blood group exhibited the most positivity for TTI markers, followed by O positive blood group. Similarly, association was found between ABO group and HBsAg (p=0.01), anti-HBc (p=0.001), and anti-HCV (p<0.001) markers positivity.ConclusionEmphasis on implementing robust screening measures for donated blood is underscored by this study. There is the need for future study to extensively evaluate TTI status to enhance our understanding of the trend in TTI.Copyright: © Saudi Medical Journal.

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