• Aliya A Khan, Riemer H J A Slart, Dalal S Ali, Oliver Bock, John J Carey, Pauline Camacho, Klaus Engelke, Paola A Erba, Nicholas C Harvey, Willem F Lems, Sarah Morgan, Kendall F Moseley, Christopher O'Brien, Linda Probyn, Marija Punda, Bradford Richmond, John T Schousboe, Christopher Shuhart, Kate A Ward, E Michael Lewiecki, and International Working Group on DXA Best Practices.
• Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada. Electronic address: aliya@mcmaster.ca.
• Mayo Clin. Proc. 2024 Jul 1; 99 (7): 112711411127-1141.

AbstractOsteoporotic fractures, also known as fragility fractures, are reflective of compromised bone strength and are associated with significant morbidity and mortality. Such fractures may be clinically silent, and others may present clinically with pain and deformity at the time of the injury. Unfortunately, and even at the time of detection, most individuals sustaining fragility fractures are not identified as having underlying metabolic bone disease and are not evaluated or treated to reduce the incidence of future fractures. A multidisciplinary international working group with representation from international societies dedicated to advancing the care of patients with metabolic bone disease has developed best practice recommendations for the diagnosis and evaluation of individuals with fragility fractures. A comprehensive narrative review was conducted to identify key articles on fragility fractures and their impact on the incidence of further fractures, morbidity, and mortality. This document represents consensus among the supporting societies and harmonizes best practice recommendations consistent with advances in research. A fragility fracture in an adult is an important predictor of future fractures and requires further evaluation and treatment of the underlying osteoporosis. It is important to recognize that most fragility fractures occur in patients with bone mineral density T scores higher than -2.5, and these fractures confirm the presence of skeletal fragility even in the presence of a well-maintained bone mineral density. Fragility fractures require further evaluation with exclusion of contributing factors for osteoporosis and assessment of clinical risk factors for fracture followed by appropriate pharmacological intervention designed to reduce the risk of future fracture. Because most low-trauma vertebral fractures do not present with pain, dedicated vertebral imaging and review of past imaging is useful in identifying fractures in patients at high risk for vertebral fractures. Given the importance of fractures in confirming skeletal fragility and predicting future events, it is recommended that an established classification system be used for fracture identification and reporting.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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