• Marcus Fernando da Silva Praxedes, Mayara Sousa Vianna, Waleska Jaclyn Freitas Nunes de Sousa, Frederico Bartolazzi, Vânia Eloisa de Araújo, and Parreiras MartinsMaria AuxiliadoraMAFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte.Faculdade de Medicina and Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil..
• Centro de Ciências da Saúde, Universidade Federal do Recôncavo da Bahia, Santo Antônio de Jesus, Bahia.
• Medicine (Baltimore). 2019 Oct 1; 98 (42): e17323e17323.

BackgroundNon-adherence can be highlighted as one of the main contributors to the occurrence of adverse events in patients treated with warfarin. The usefulness of self-reporting measures of drug adherence could be improved by following psychometric properties in the development of the measurement scales. Thus, we aimed to describe the protocol of a systematic literature review designed to investigate and describe validated instruments used to assess adherence to warfarin therapy.MethodsWe will perform a systematic review will include observational and experimental studies involving the use of validated instruments to assess adherence to warfarin therapy. Dimensions of adherence raised by the selected studies will be extracted to be compared. We will systematically search electronic databases including MEDLINE, LILACS, EMBASE, and Cochrane Library using a comprehensive strategy from inception to June 31, 2019. Two reviewers will revise the literature independently using a standardized form and assess the potential bias. After the comparison of results, discrepancies will be solved after the analysis of a third reviewer.ResultThe development of the present systematic will help to summarize and evaluate the validated instruments that have been previously published to assess adherence to warfarin therapy.ConclusionThis review will substantiate the discussion of relevant topics that should be assessed while providing care to patients taking warfarin. This knowledge will enable a comprehensive approach for healthcare professionals to improve treatment outcomes and the design of future investigations.RegistrationThe systematic review is registered in the PROSPERO international prospective register of systematic review (PROSPERO# CRD42019128324).

10 keywords...

hide…