• Julián Olalla, José M García de Lomas, Natalia Chueca, Xavier Pérez-Stachowski, Adolfo De Salazar, Alfonso Del Arco, Julio Plaza-Díaz, Javier De la Torre, José Luis Prada, Javier García-Alegría, Fernando Fernández-Sánchez, and Federico García.
• Servicio de Medicina Interna, Hospital Costa del Sol, Marbella.
• Medicine (Baltimore). 2019 Oct 1; 98 (42): e17528e17528.

BackgroundExtra virgin olive oil (EVOO) has shown beneficial effects on the lipid profile and inflammatory parameters in general population. Our goal is to analyze these changes together with those of intestinal microbiota in human immunodeficiency virus (HIV)-infected patients over 50 years of age.MethodsExperimental single arm open study. HIV patients over the age of 50 with undetectable viral load were selected. EVOO was distributed among the patients so that each one consumed 50 g daily for 12 weeks. Lipid profile, C-reactive protein (CRP), and intestinal microbiota composition were analyzed at the beginning and at the end of the intervention.ResultsTotal cholesterol decreased significantly (5 mg/dL), and a nonsignificant decrease in low-density lipoprotein cholesterol (12 mg/dL), triglycerides (21 mg/dL), and CRP (1.25 mg/dL) was observed. There was a significant increase in alpha diversity after the intervention in men and a decrease in proinflammatory genera such as Dethiosulfovibrionaceae was observed. Differences were also observed in the microbiota of men and women and according to the type of antiretroviral treatment.ConclusionSustained consumption of 50 g of EVOO in elderly HIV-infected patients might be associated with an improvement in lipid profile and alfa diversity of intestinal microbiota.

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