• Arch Med Sci · Jan 2024

    Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma.

    • Chuanxi Sun, Ziqi Zhou, Fangqiang Liu, Hong Li, and Zhe Liu.
    • Department of Orthodontics, The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
    • Arch Med Sci. 2024 Jan 1; 20 (3): 102210281022-1028.

    IntroductionTo investigate the toxicity of combretastatin A4 phosphate (CA4P) hyaluronic acid (HA) gel nanoparticles (HA-CA4P-NPs) in OSCC (oral squamous cell carcinoma).MethodsToxicity was investigated using fluorescence microscopy, MTT assay, flow cytometry, and OSCC xenograft mouse models.ResultsCompared with CA4P, HA-CA4P-NPs generated nearly 10 times more fluorescence in OSCC cells. Cytotoxicity assays showed that HACA4P-NPs were more toxic to SCC-4 cells but not to HNECs. Remarkable necrosis was induced in SCC-4 cells after exposure to HA-CA4P-NPs, and related proteins were upregulated. Furthermore, HA-CA4P-NPs significantly reduced the tumour size.ConclusionsHA-CA4P-NPs improved drug release and delivery, and increased cytotoxicity to cancer cells.Copyright: © 2024 Termedia & Banach.

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