• Arch Med Sci · Jan 2024

    Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis.

    • Xiaoshu Liu, Daoyan Tang, Min Qi, and Jian-Qing He.
    • Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
    • Arch Med Sci. 2024 Jan 1; 20 (3): 103810421038-1042.

    IntroductionTuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.MethodsWe searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.ResultsOur findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), p = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), p < 0.001) in TBM patients.ConclusionsThe analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.Copyright: © 2024 Termedia & Banach.

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