• Arch Med Sci · Jan 2024

    Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis.

    • Tannaz Jamialahmadi, Luis E Simental-Mendia, Ali H Eid, Wael Almahmeed, Sepideh Salehabadi, Khalid Al-Rasadi, Maciej Banach, and Amirhossein Sahebkar.
    • Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
    • Arch Med Sci. 2024 Jan 1; 20 (3): 9971001997-1001.

    IntroductionUnderstanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.MethodsThe study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.ResultsIn the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = -0.507, 95% CI: -2.536, 1.521, p = 0.021).ConclusionsStatins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.Copyright: © 2024 Termedia & Banach.

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