• Li Guan, Yuyang Tang, Zhenglin Yang, Lijuan Guo, and Sen Yang.
• School of Stomatology, Zunyi Medical University, Zunyi, China.
• Medicine (Baltimore). 2024 Jul 26; 103 (30): e39150e39150.

RationaleHyalinizing clear cell carcinoma (HCCC) of the salivary glands is a rare low-grade malignant tumor. This type of tumor is particularly uncommon in the sublingual glands.Patient ConcernsA 57-year-old female with a mass on the left side of the floor of the mouth that had been present for 2 months. The computed tomography scan of the neck revealed a nodular abnormal density shadow in the left sublingual area, measuring approximately 2.6 cm × 1.9 cm.DiagnosesPrimary HCCC of the sublingual gland.InterventionsThe patient underwent surgical treatment and reconstruction using a left anterolateral femoral free flap, which showed immunohistochemical positivity for CK 5/6, CK 7, CK (AE1/AE3), and Ki-67 (<5%), but negative for SMA and S-100.OutcomesNo recurrence was observed during the 12-month postoperative follow-up period.LessonsThe absence of characteristic clinical manifestations makes HCCC highly susceptible to misdiagnoses. This case presents a rare instance of HCCC in the sublingual gland, providing a reference for the clinical diagnosis and treatment of the disease.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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