• Cleve Clin J Med · Jul 2024

    Review

    Preventing herpes zoster in immunocompromised patients: Current concepts.

    • Cassandra Calabrese, Elizabeth Kirchner, James Fernandez, and Leonard H Calabrese.
    • Department of Rheumatologic and Immunologic Disease, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
    • Cleve Clin J Med. 2024 Jul 1; 91 (7): 437445437-445.

    AbstractHerpes zoster (HZ) incidence is much higher in immunocompromised individuals than in immunocompetent individuals. HZ also occurs at a younger age and is often more severe in immunocompromised persons. Preventive strategies center around the recombinant zoster vaccine (RZV), which is approved for immunocompromised adults age 19 and older. Identifying those at greatest risk is critical. For those considering vaccination, evidence gaps regarding vaccine efficacy, toxicity, length of protection, and potential effects on underlying conditions may complicate shared and informed decision-making. Recent data have filled some of these gaps, with several societies issuing recommendations regarding vaccination. Remaining gaps are currently addressed by expert opinion.Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.

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