• Revista médica de Chile · Aug 2023

    [Effect of Sedentary behaviors on the Interaction Between the FTO Gene and Adiposity Levels in Chilean Adults - Results from the GENADIO Study].

    • Carlos Celis-Morales, Marcelo Villagrán, Lorena Mardones, María Adela Martínez-Sanguinetti, Ana María Leiva-Ordoñez, Fernanda Carrasco-Marín, Natalia Ulloa, Miquel Martorell, Nicole Lasserre-Laso, Ximena Díaz-Martinez, Igor Cigarroa, Yeny Concha-Cisternas, Claudia Troncoso-Pantoja, Fabian Lanuza, Jaime Vásquez-Gómez, Solange Parra-Soto, and Fanny Petermann-Rocha.
    • School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.
    • Rev Med Chil. 2023 Aug 1; 151 (8): 980991980-991.

    BackgroundThe Fat-mass and obesity-associated-gene (FTO gene) and sedentary behavior time are associated with obesity. However, whether sedentary behavior time can modify the genetic predisposition to obesity in the Chilean population is unknown. Therefore, this study investigated the association between sedentary behavior, adiposity markers, and the FTO gene.MethodsThis cross-sectional study included 409 participants from the Genes, Environment, Diabetes, and Obesity (GENADIO) study. Adiposity markers studied included body weight, body mass index (BMI), waist circumference (WC), and fat mass. Sedentary behaviors were measured using accelerometers. Using multiple regression, we evaluated the interaction between sedentary behaviors and the FTO gene (rs9939609) on adiposity markers.ResultsSedentary behaviors and the FTO genotype were positively associated with higher body weight, BMI, WC, and fat mass. However, the association between time of sedentary behavior and adiposity markers was higher in carriers of the risk variant for the FTO gene. For each hour of increment in sedentary behaviors, body weight increases by 1.36 kg ([95% CI: 0.27; 2.46], p = 0.015) and 2.95 kg ([95%CI: 1.24; 4.65], p = 0.001) in non-risk carriers (TT) versus risk carriers (AA), respectively. We observed similar results for WC, BMI, and body fat, but the interaction was significant only for WC.ConclusionThe association between sedentary behaviors and adiposity markers, especially body weight and WC, is higher in individuals who carry the risk variant of the FTO gene.

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