• Pak J Med Sci · Aug 2024

    Effects of ganciclovir combined with recombinant human interferon-α on clinical efficacy and immune function in children with infectious mononucleosis.

    • Ling Sun, Jing Bi, Weina Zhen, Meiying Wang, and Haobin Song.
    • Ling Sun, Department of Otology, Baoding Key Laboratory of Clinical Research on Children's Respiratory and Digestive Diseases, Department of Ophthalmology and Otorhinolaryngology, Baoding, Hebei, China. Department of Infectious Diseases, Beijing Children's Hospital Affiliated to Capital Medical University Baoding Hospital, Baoding 071000, Hebei, P.R. China.
    • Pak J Med Sci. 2024 Aug 1; 40 (7): 147314781473-1478.

    ObjectiveTo evaluate the effects of ganciclovir combined with recombinant human interferon on clinical efficacy and immune function of children with infectious mononucleosis(IM).MethodsThis was a retrospective study. Children (n=120) with IM hospitalized in Beijing Children's Hospital Affiliated to Capital Medical University Baoding Hospital from January 2020 to January 2022 were selected and randomly divided into study group and control group((n=60). Patients in the control group were treated with ganciclovir by intravenous infusion, and patients in the study group were given ganciclovir+recombinant human interferon-α1b. The time for eliminating clinical symptoms, the levels of inflammatory cytokines, immune function condition and T-lymphocyte subsets between the two groups were compared and analyzed.ResultsAfter treatment, the time for body temperature returned to normal, time for recovery from cervical lymphadenopathy, time for recovery from hepatosplenomegaly and time for disappearance of angina and oral mucosal congestion in the study group were significantly shorter than those in the control group(p= 0.00); after treatment, the levels of TNF-a and IL-6 in the study group were significantly lower than those in the control group; the indexes of CD3+ and CD8+ in the study group were significantly lower than those in the control group; after treatment, the levels of CD4+ and CD4+/CD8+ in the study group were significantly higher than those in the control group.ConclusionRanciclovir combined with recombinant human interferon-α1b, rapid improvements of clinical symptoms, significantly decreased inflammatory cytokines, improved T-lymphocyte function and no significant increase in adverse drug reactions were found in children with IM.Copyright: © Pakistan Journal of Medical Sciences.

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