• Acta Anaesthesiol Scand · Nov 2024

    Review

    Opioids and personalized analgesia in the perioperative setting: A protocol for five systematic reviews.

    • KarlsenAnders Peder HøjerAPH0000-0002-0338-3751Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Pernille Bjersand Sunde, Markus Harboe Olsen, Jens Laigaard, Caroline Folkersen, Trang Xuan Minh Tran, Ida Houtved Rasmussen, Selma Kjartansdóttir, Atena Saito, Michael Asger Andersen, Mathias Maagaard, Nicholas Papadomanolakis-Pakis, Kim Dalhoff, Lone Nikolajsen, Troels Haxholdt Lunn, Christian Sylvest Meyhoff, Janus Christian Jakobsen, and Ole Mathiesen.
    • Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
    • Acta Anaesthesiol Scand. 2024 Nov 1; 68 (10): 157315801573-1580.

    BackgroundTreatment with opioids is a mainstay in perioperative pain management. While the leading treatment paradigm has been procedure-specific pain management, efforts regarding personalized pain treatment are increasing. The OPI•AID project aims to develop personalized algorithms for perioperative pain management, taking demographic, surgical, and anaesthesiologic factors into account. We will undertake five parallel reviews to illuminate current evidence on different aspects of individual responses to perioperative opioid treatment.MethodsInclusion of adult populations in English-written studies. Review-specific searches are developed for the following databases: CENTRAL, MEDLINE, Embase, clinicaltrials.gov, and clinicaltrial.eu. Two authors will independently screen citations, extract data, and assess the risks of bias in each review (QUIPS, PROBAST and RoB2, as relevant).ConclusionThese reviews will evaluate various aspects of perioperative opioid treatment, including individualized treatment strategies, selection of specific opioids, and individual patient responses. These will guide future development of a personalized perioperative opioid treatment algorithm (OPI•AID) that will be validated and tested clinically against standard of care.© 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

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