• Nihal Çallıoğlu, Derya K Gül, İlke Ö Arslan, İpek Geyikoğlu, and Ergül Demirçivi.
• From the Department of Perinatology (Çallıoğlu); from the Department of Obstetrics and Gynecology (Geyikoğlu), Başakşehir Çam and Sakura City Hospital, from the Department of Obstetrics and Gynecology (Gül), Medipol University School of Medicine Health, from the Department of Obstetrıc and Gynecology (Demirçivi), Clinic of Obstetrics and Gynecology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, and from the Department of Obstetrics and Gynecology (Arslan), Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
• Saudi Med J. 2024 Aug 1; 45 (8): 808813808-813.

ObjectivesTo uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss.MethodsA total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years old who experienced EPL. The control group comprised healthy pregnant women who gave birth at ≥37 weeks.ResultsThe EPL group had significantly lower plateletcrit (p=0.04), platelet distribution width (PDW, p<0.0001), and RDW (p<0.0001) and higher monocyte (p<0.0001) and SIRI (p<0.0001) values than the control group. The hemoglobin, white blood cells, platelet count, neutrophil count, lymphocyte count, mean platelet volume, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII values were not significantly different between the EPL and control groups (p>0.05). The cut-off value for the SIRI that offers the best sensitivity/specificity balance was 1.48 (sensitivity of 63%; specificity of 63%) in the receiver operating characteristics curve. Among the inflammatory parameters for predicting EPL, PDW had highest specificity (84%), and RDW had the highest sensitivity (80%).ConclusionThis study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker than NLR, PLR, MLR, and SII in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.Copyright: © Saudi Medical Journal.

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