• Sergey Efremov, Angela Zagatina, Alexey Filippov, Mikhail Ryadinskiy, Maxim Novikov, and Dmitry Shmatov.
• Saint-Petersburg State University Hospital, Saint-Petersburg, Russian Federation. Electronic address: sergefremov@mail.ru.
• J. Cardiothorac. Vasc. Anesth. 2024 Oct 1; 38 (10): 245924702459-2470.

AbstractCardiac relaxation is a complex process that involves various interconnected characteristics and, along with contractile properties, determines stroke volume. Perioperative ischemia-reperfusion injury and left ventricular diastolic dysfunction (DD) are characterized by the left ventricle's inability to receive a sufficient blood volume under adequate preload. Baseline DD and perioperative DD have an impact on postoperative complications, length of hospital stay, and major clinical outcomes in a variety of cardiac pathologies. Several baseline and perioperative factors, such as age, female sex, hypertension, left ventricle hypertrophy, diabetes, and perioperative ischemia-reperfusion injury, contribute to the risk of DD. The recommended diagnostic criteria available in guidelines have not been validated in the perioperative settings and still need clarification. Timely diagnosis of DD might be crucial for effectively treating postoperative low cardiac output syndrome. This implies the need for an individualized approach to fluid infusion strategy, cardiac rate and rhythm control, identification of extrinsic causes, and administration of drugs with lusitropic effects. The purpose of this review is to consolidate scattered information on various aspects of diastolic dysfunction in cardiac surgery and provide readers with well-organized and clinically applicable information.Copyright © 2024 Elsevier Inc. All rights reserved.

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