• Shuailei Wang, Jiaming Ji, Chang Xiong, Weilong Zhong, Liping Li, Shengyuan Gong, Jiamei Lu, Ziqing Hei, Weifeng Yao, and Chaojin Chen.
• Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
• J Clin Anesth. 2024 Nov 1; 98: 111586111586.

Study ObjectiveHypoxemia is the most frequent adverse event observed during gastrointestinal endoscopy under procedural sedation. An optimum oxygen therapy has still not been conclusively determined.DesignA systematic review and network meta-analysis of randomized clinical trials.SettingDigestive Endoscopy Center.PatientsAdults (≥18 years old and of both sexes) during gastrointestinal endoscopy under procedural sedation.InterventionsPubmed, MEDLINE, Web of Science, Embase, and Clinicaltrials.gov. were searched until June 30, 2023. Randomized clinical trials (RCTs) comparing any oxygen therapy with another oxygen therapy or with placebo (nasal cannula, NC) were included.MeasurementThe primary outcome was the incidence of hypoxemia, defined as the pulse oxygen saturation (SpO2). Random-effects network meta-analyses were performed. Data are reported as odds ratios (OR), prediction intervals (PrI) and 95% CI. Bias risk was evaluated following the guidelines outlined by the Cochrane Collaboration. The quality of evidence was evaluated through the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.Main ResultsWe included 27 RCTs with a total of 7552 patients. Compared to the use of NC, non-invasive positive pressure ventilation (NIPPV) demonstrated superior efficacy in mitigating hypoxemia (NIPPV vs. NC, OR = 0.16, 95% CI: 0.08-0.31, 95% PrI: 0.06-0.41), followed by Wei nasal jet tube (WNJT) (WNJT vs. NC, OR = 0.17, 95% CI: 0.10-0.30, 95% PrI: 0.07-0.42). The efficacy for preventing hypoxemia was ranked as follows: NIPPV > WNJT > oropharynx/nasopharyngeal catheter > high-flow nasal oxygenation > nasal mask > NC.ConclusionsDuring gastrointestinal endoscopy under procedural sedation, all other advanced oxygen therapies were found to be more efficacious than nasal cannula. NIPPV and WNJT appear to be the most efficacious oxygen therapy for preventing hypoxemia. Additionally, clinicians should make a choice regarding the most suitable oxygen therapy based on the risk population, type of endoscopy and adverse events.Copyright © 2024 Elsevier Inc. All rights reserved.

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