• Chinese medical journal · Oct 2024

    Review

    Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma.

    • Chengji Wang and Liang Wang.
    • Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
    • Chin. Med. J. 2024 Oct 5; 137 (19): 230823242308-2324.

    AbstractNatural killer/T cell lymphoma (NKTCL) is a malignant tumor originating from NK or T cells, characterized by its highly aggressive and heterogeneous nature. NKTCL is predominantly associated with Epstein-Barr virus infection, disproportionately affecting Asian and Latin American populations. Owing to the application of asparaginase and immunotherapy, clinical outcomes have improved significantly. However, for patients in whom first-line treatment fails, the prognosis is exceedingly poor. Overexpression of multidrug resistance genes, abnormal signaling pathways, epigenetic modifications and active Epstein-Barr virus infection may be responsible for resistance. This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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