• Mengmeng Yuan, Lijun Wu, Wen Li, and Shuwen Li.
• School of Nursing, Anhui Medical University, Hefei, Anhui, People's Republic of China.
• Patient Prefer Adher. 2024 Jan 1; 18: 175517661755-1766.

PurposeWe intended to explore the chain mediation role of resilience and different sources of social support on the relationship between symptom interference and life satisfaction from the patient-reported perspective.Patients And MethodsTwo hundred and twenty-six patients after esophagectomy were investigated using four validated scales to estimate the symptom interference, resilience, different sources of social support, and life satisfaction. The chain mediation analysis was conducted using SPSS PROCESS Macro Model 6.ResultsMediation analysis showed that symptom interference indirectly influenced life satisfaction through two significant mediating pathways: (i) resilience (B = -0.138, 95% CI: -0.194 to -0.091); (ii) the chain mediators involving in resilience and family support (B = -0.049, 95% CI: -0.073 to -0.026). Surprisingly, the mediating pathway of family support was not significant.ConclusionInterventions for resilience and family support could mitigate the adverse effects of symptom interference in patients after esophagectomy, improving life satisfaction. Of these, resilience may be more critical in terms of the utilization of social resources than family support.© 2024 Yuan et al.

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