• Sigri Kløve, Sara E Stinson, Fie O Romme, Julia Butt, Katrine B Graversen, Morten A V Lund, Cilius E Fonvig, Tim Waterboer, Guillermo I Perez-Perez, Torben Hansen, Jens-Christian Holm, and Sandra B Andersen.
• Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 1353, Denmark. sigri.kloeve@sund.ku.dk.
• Bmc Med. 2024 Sep 11; 22 (1): 379379.

BackgroundHelicobacter pylori colonizes the human stomach and may affect the inflammatory response, hormone production related to energy regulation, and gastrointestinal microbiota composition. Previous studies have explored a potential association between H. pylori infection and pediatric obesity with varying results. Considering the immunomodulatory effects of early-life infection with H. pylori that can confer beneficial effects, we hypothesized that we would find an inverse relationship between H. pylori seropositivity and obesity among Danish children and adolescents.MethodsWe assessed H. pylori seroprevalence in 713 subjects from an obesity clinic cohort and 990 subjects from a population-based cohort, aged 6 to 19 years, and examined its association with obesity and other cardiometabolic risk factors.ResultsNo association was found between H. pylori and body mass index standard deviation score (BMI SDS). H. pylori seropositivity was, however, significantly associated with higher fasting plasma glucose levels and the prevalence of hyperglycemia.ConclusionWhile we did not find an association between H. pylori seropositivity and BMI SDS, we observed a significant association with higher fasting plasma glucose levels and increased prevalence of hyperglycemia, suggesting that H. pylori infection may contribute to impaired glucose regulation in Danish children and adolescents.© 2024. The Author(s).

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