• Marie Kanstrup, Laura Singh, Elisabeth Johanna Leehr, Katarina E Göransson, Sara Ahmed Pihlgren, Lalitha Iyadurai, Oili Dahl, Ann-Charlotte Falk, Veronica Lindström, Nermin Hadziosmanovic, Katja Gabrysch, Michelle L Moulds, and Emily A Holmes.
• Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
• Bmc Med. 2024 Sep 19; 22 (1): 403403.

BackgroundIntrusive memories of psychologically traumatic events bring distress both sub-clinically and clinically. This parallel-group, two-arm randomised controlled trial evaluated the effect of a brief behavioural intervention on reducing intrusive memories in frontline healthcare workers exposed to traumatic events during the COVID-19 pandemic.MethodsParticipants with at least two intrusive memories of work-related trauma in the week before recruitment were randomised 1:1 to an imagery-competing task intervention (n = 73) or attention-based control task (n = 71). The number of intrusive memories was assessed at baseline and 5 weeks after the guided session (primary endpoint).ResultsThe intervention significantly reduced intrusive memory frequency compared with control [intervention Mdn = 1.0 (IQR = 0-3), control Mdn = 5.0 (IQR = 1-17); p < 0.0001, IRR = 0.30; 95% CI = 0.17-0.53] and led to fewer post-traumatic stress-related symptoms at 1, 3 and 6 month follow-ups (secondary endpoints). Participants and statisticians were blinded to allocation. Adverse events data were acquired throughout the trial, demonstrating safety. There was high adherence and low attrition.ConclusionsThis brief, single-symptom, repeatable digital intervention for subclinical-to-clinical samples after trauma allows scalability, taking a preventing-to-treating approach after trauma.Trial Registration2020-07-06, ClinicalTrials.gov identifier: NCT04460014.© 2024. The Author(s).

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