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- Christopher James Mikulas, Kabeer Ali, and Nirmal Onteddu.
- University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.
- J. Investig. Med. 2024 Oct 15: 1081558924127941410815589241279414.
AbstractProstate cancer screening has presented a challenge to clinicians. Although the implementation of screening tests such as prostate-specific antigen (PSA) and digital rectal exam (DRE) has had a significant impact on prostate-cancer-specific mortality, these traditional screening tests have a relatively poor positive predictive value of clinically significant prostate cancer (CSPC), leading to unnecessary biopsies and treatment with a host of potential complications. Fortunately, much research has been done to optimize prostate cancer screening. This includes the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, which underwent a secondary analysis to identify an association between PSA level and CSPC, and the IP1-PROSTAGRAM Tri.
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