• J. Investig. Med. · Jan 2025

    Review

    EXPRESS: Prostate Cancer Screening: Is it Time for a New Approach? A Review Article.

    • Christopher James Mikulas, Kabeer Ali, and Nirmal Onteddu.
    • University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.
    • J. Investig. Med. 2025 Jan 1; 73 (1): 273427-34.

    AbstractProstate cancer screening has presented a challenge to clinicians. Although the implementation of screening tests such as prostate-specific antigen (PSA) and digital rectal exam (DRE) has had a significant impact on prostate-cancer-specific mortality, these traditional screening tests have a relatively poor positive predictive value of clinically significant prostate cancer (CSPC), leading to unnecessary biopsies and treatment with a host of potential complications. Fortunately, much research has been done to optimize prostate cancer screening. This includes the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, which underwent a secondary analysis to identify an association between PSA level and CSPC, and the IP1-PROSTAGRAM Tri.

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