• Pierre Gazengel, R Hindre, F Jeny, S Mendes, J Caliez, O Freynet, C Rotenberg, M Didier, R Dhote, Y Cohen, Y Uzunhan, D Bouvry, and H Nunes.
• Service de pneumologie, Centre de référence des maladies pulmonaires rares (site constitutif), hôpital Avicenne, Assistance Publique Hôpitaux de Paris, UMR Inserm U1272, Université Sorbonne Paris Nord, Bobigny, France. Electronic address: pierre.gazengel@gmail.com.
• Chest. 2024 Aug 28.

BackgroundSarcoidosis is an idiopathic systemic granulomatosis whose evolution is self-limiting in most cases. However, it can progress to organ damage that menaces the vital or functional prognosis of patients. Sarcoidosis itself, but also its comorbidities, can pose a threat to the patient, require rapid initiation of treatment, and justify emergency hospitalization.Research QuestionWhat are the reasons and prognosis of patients with sarcoidosis hospitalized in emergency?Study Design And MethodsThe objectives of our study were to describe the causes of admission, and to identify predictors of mortality in patients with sarcoidosis hospitalized in emergency. This is a retrospective monocentric study. We included patients hospitalized after a stay in the ED or ICU, or requiring an unscheduled hospitalization after telephone advice or a consultation, between January 1, 2017 and July 7, 2020.ResultsWe identified 154 patients with sarcoidosis hospitalized in emergency, among which 14 (9%) required the ICU. There were 81 men, with a median age of 55.0 years (interquartile range, 44.0-67.0). Sarcoidosis was inaugural in 20 patients (14%). The primary reason for hospitalization was lower respiratory infections in 32 patients (21%), followed by acute pulmonary exacerbation of sarcoidosis in 17 (11%), suspected cardiac sarcoidosis in 13 (8.4%), and neurosarcoidosis in 12 (7.7%). The median length of stay was 6 days (interquartile range, 3.00-10.0). In-hospital mortality rate was 3.9%. The 2-year transplantation-free survival after hospitalization was 86.8% (95% CI, 81.4-92.5). The factors associated with a worse transplantation-free survival were Charlson Comorbidity Index (hazard ratio [HR], 1.29; 95% CI, 1.04-1.61; P = .021), pulmonary hypertension (HR, 2.53; 95% CI, 1.10-5.83; P = .029), and oxygen therapy during hospitalization (HR, 4.18; 95% CI, 1.55-11.29; P = .005).InterpretationThe overall mortality of patients with sarcoidosis hospitalized in emergency is high. The presence of comorbidities and the severity of respiratory failure, as reflected by oxygen requirement, are important prognostic determinants.Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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