• Cleve Clin J Med · Sep 2024

    Review

    The RSV roadmap in children: Lessons learned, paths forward.

    • Ruchita Negi, Jonathan Shabab, and Frank Esper.
    • Center for Pediatric Infectious Diseases, Department of Pediatrics. Cleveland Clinic Children's, Cleveland, OH.
    • Cleve Clin J Med. 2024 Sep 4; 91 (9 suppl 1): S19S25S19-S25.

    AbstractRespiratory syncytial virus (RSV) is a threat to infants globally causing bronchiolitis and pneumonia. Despite decades of research, RSV outbreaks occur with only modest advancements in prevention or treatment. Vaccine development faced challenges because past attempts caused enhanced disease and treatment options demonstrated limited efficacy. Recent advancements, including maternal vaccines focusing on the prefusion form of the F glycoprotein are now showing significant benefits in preventing severe RSV-related illness in infants. Additionally, monoclonal antibodies offer prevention directly to newborns within 1 week of birth. These innovations have the potential to substantially change the impact of RSV.Copyright © 2024 The Cleveland Clinic Foundation. All Rights Reserved.

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